Scientists have discovered a protein in zebrafish, named HMG-A1, which has the ability to activate dormant genes and potentially restore weak hearts in mice. This breakthrough discovery offers new hope for restoring heart health in humans.
Researchers from the Heubercht Institute’s Bakker group successfully used the zebrafish protein to heal heart issues in mice. The protein, HMG-A1, was identified as being crucial in promoting heart health restoration in zebrafish.
In the study, HMG-A1 effectively activated dormant genes in mice, enabling heart health recovery without adverse effects, such as heart enlargement.
This successful research, conducted in collaboration with the Dutch Heart Foundation and HeartKind Foundation, marks a significant advancement in developing regenerative therapies to combat heart failure.
The findings were published in the Nature Cardiovascular Research journal.
