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Scientists at the Center of Excellence for Brain Tumor Research at the University of Plymouth have used the humble fruit fly Drosophila to gain insight into stopping the growth of brain tumours.
Using the fruit fly model, the researchers successfully identified and examined cells in their earliest stages of growth. This pioneering approach has particularly shed light on glioma tumors, including aggressive variants such as glioblastoma.
Characterized by rapid growth and infiltration of healthy brain tissue, glioblastomas present a formidable challenge for treatment with poor survival rates. Symptoms such as worsening headaches, nausea, blurred vision and seizures are indicative of brain tumors.
The significance of this research goes beyond mere academic curiosity. Glioblastomas, although they can affect individuals of any age, are more common in older adults.
By delving into the molecular mechanisms underlying tumor growth in these tiny insects, scientists are paving the way for potential therapeutic interventions that could ultimately benefit patients battling these devastating brain tumors.
According to Dr. Claudia Barroso, their research sheds light on preparatory mechanisms crucial for tumor development. Using the Drosophila propeller as a model, the team examined cells in the early stages of brain tumor formation and revealed marked differences in metabolic and protein balance compared to normal cells.
Dr. Karen Noble, from the charity Brain Tumor Research, highlighted the potential of these early discoveries to develop more effective treatments targeting tumor cells, improving patient outcomes.
This innovative study underscores the importance of unconventional model organisms in biomedical research and offers hope for more effective treatments in the ongoing fight against glioblastoma and other malignant brain tumors.
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